Acute hepatitis E virus

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It is an infectious disease caused by the hepatitis E virus that inflames the liver. 

It is more frequent in developing countries where access to drinking water is limited and hygienic conditions are poor. It generally affects adolescents and can be especially serious in pregnant women.

The virus is transmitted by drinking water contaminated by the feces of people who have the infection; it may also be transmitted by the use of ice made from contaminated water. In more developed countries, the most common route of infection is the ingestion of undercooked meat, usually pork or venison. 

A high percentage of infected persons show no symptoms. When they do, it is usually in the form of tiredness, general malaise, loss of appetite, nausea and vomiting, dark-colored urine, whitish feces and yellowish skin and eyes.
In people with other liver diseases, hepatitis E virus infection can lead to severe liver failure.

It is diagnosed by clinical questioning and after analysis of a blood sample where the virus will be detected in the acute phase, or the presence of antibodies if the disease has already passed. 

Treatment is symptomatic, soothing the itching of the skin with cholestyramine and ensuring proper hydration and adequate rest. There is currently no vaccine to protect against hepatitis E virus infection. 

The vast majority of people get better within a few weeks without treatment. It rarely becomes a chronic infection, being more likely in people with permanently low defenses, either by immunosuppressive treatments or infections such as HIV.

Bibliographic references
  1. Clemente-Casares P, Pina S, Buti M, et al. Hepatitis E virus epidemiology in industrialized countries. Emerg Infect Dis 2003; 9:448.
  2. Andonov A, Robbins M, Borlang J, et al. Rat Hepatitis E Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient. J Infect Dis 2019; 220:951.
  3. Kuniholm MH, Purcell RH, McQuillan GM, et al. Epidemiology of hepatitis E virus in the United States: results from the Third National Health and Nutrition Examination Survey, 1988-1994. J Infect Dis 2009; 200:48.
  4. Izopet J, Tremeaux P, Marion O, et al. Hepatitis E virus infections in Europe. J Clin Virol 2019; 120:20.
  5. The Lancet . Growing concerns of hepatitis E in Europe. Lancet 2017; 390:334.
Author
Dr. Oscar Garcia-Esquirol
Copyright
© TeckelMedical 2026

Symptoms

    Yellow tinge to skin and mucous membranes


    Whitish stools


    Yellow-tinged eyes


    Dark urine, the color of cola


    Upper right abdominal pain

Symptoms to watch out for

Signs of dehydration: more tiredness than usual, dizziness, dry mouth and tongue.
Reduction in the level of consciousness

Self-care

Maintain a fluid intake of 6 - 8 cups per day.