Amphetamine or amphetamine-derivatives poisoning - Ecstasy and designer drugs

Medium urgency
CommonModerately severe

Ecstasy is the name used to refer to an amphetamine derivative MDMA, a prototype of the so-called "designer drugs". They come from drugs that never reached the marketing stage. Their consumption has spread rapidly due to the false notion of consumers that they are not toxic and do not entail any risk to your health. Toxicity and death may occur after consuming a single tablet.

The subjective immediate states include euphoria, increase in energy and excitement and ability to "connect". Depression may sometimes appear, which can last for months.

Poisoning due to MDMA may cause a myriad of dangerous effects, including severe hypertension, hyperthermia, delirium, psychomotor agitation and hyponatremia. All of these are potentially life-threatening complications. It is diagnosed by clinical suspicion, although infectious diseases that can cause similar symptoms must be ruled out. If the consumption was very recent, a dose of activated charcoal will be administered. In addition, supportive treatment will be performed for the symptoms to correct laboratory test abnormalities, treatment of hypertension, agitation, coagulation disorders, etc. In cases of severe poisoning, admission to ICU and even artificial respiration may be required.

Bibliographic references
  1. Robert J Hoffman. MDMA (ecstasy) intoxication. UpToDate. Apr 2016
  2. Armenian P, Mamantov TM, Tsutaoka BT, et al. Multiple MDMA (Ecstasy) overdoses at a rave event: a case series. J Intensive Care Med 2013; 28:252.
  3. Amoroso T. The Psychopharmacology of ±3,4 Methylenedioxymethamphetamine and its Role in the Treatment of Posttraumatic Stress Disorder. J Psychoactive Drugs 2015; 47:337.
  4. Rochester JA, Kirchner JT. Ecstasy (3,4-methylenedioxymethamphetamine): history, neurochemistry, and toxicology. J Am Board Fam Pract 1999; 12:137.
  5. Nancy K. Mello. Cocaína y otras drogas de abuso frecuente. Harrison. Principios de Medicina Interna, 19e. Cap 469e
Author
Dr. Patricia Sánchez
Copyright
© TeckelMedical 2026

Symptoms

    Excessive sweating


    Involuntary, sustained muscle contraction


    State of anxiety


    Goosebumps


    Teeth-grinding

Pre-hospital care recommendations

Call medical assistance for instructions.