Cluster headache

Low urgency
Very common-

A very severe headache involving the trigeminal nerve, typically affecting one side of the skull.

The exact cause is unknown, although it is believed to be the result of a combination of genetic predisposition and exposure to environmental factors: alcohol, nitroglycerin, perfumes, inhalation of petroleum derivatives and tobacco (up to 85% of patients are smokers).

It presents with very intense headaches in the form of attacks lasting from fifteen minutes to three hours. It usually recurs at the same time of day. It is accompanied by tearing and redness of one eye, drooping of the eyelid, nasal discharge and sweating on the same side of the face.

The diagnosis is made clinically by interview and physical examination.

Pain should be controlled with analgesics, oxygen inhalation, and relaxation techniques. Triptans (migraine medications) have been shown to be effective in reducing pain. In recurrent cases, medication such as verapamil +/- cortisone can be used to prevent recurrence.

Bibliographic references
  1. Arne, M. Cluster headache: Epidemiology, clinical features, and diagnosis. UpToDate. May 22, 2014.
  2. Goadsby, Peter J., Raskin, Neil H. Migrañas y otras cefaleas primarias. Cefalea en racimo. Harrison. Principios de Medicina Interna. Volumen 2. 19ª Edición. 2594:2596.
  3. A. Urbano-Márquez, R. Estruch. Generalidades. Cefalea acuminada (Cluster headache). Farreras Rozman. Medicina Interna. Volumen II. Duodécima edición. 1318.
Author
Dr. Oscar Garcia-Esquirol
Copyright
© TeckelMedical 2026

Symptoms

    Headache behind the eyes


    Headache at night and/or when waking up


    Headache


    Small pupil in one eye only


    Sudden headache

Symptoms to watch out for

Fever (temperature higher than 100.4 ºF)
Neck stiffness
If it is accompanied by seizures
Loss of sensibility and/or motility in limbs
If you have suffered a trauma.
Blurry vision
Vomiting

Self-care

Use over-the-counter pain relievers and consult your primary care physician to discuss other treatments.
Avoid caffeine, alcohol, smoking, and/or screen time.