Drug-induced toxicoderma encompasses skin diseases that may affect the skin, mucous membranes, hair, nails, sweat glands, etc.
Any medication can cause it. The most frequent are some antibiotics, antiepileptics and analgesics/non-steroidal anti-inflammatory drugs.
It manifests itself in a very varied way, causing reddish patches that can join together to form large red areas, welts, scaling and/or itching of the skin.
Diagnosis is made by clinical history and complete physical examination.
The first thing that should be done to treat toxicoderma is to withdraw all questionable drugs. If the reaction produced by the drug is mild, the treatment used is symptomatic, including taking antihistamines and in some cases corticosteroids, topically or orally. If the reaction is severe, hospital admission to the intensive care unit or burn unit, fluid replacement and use of antimicrobials are necessary.
- Andrew D Samel, MD, Chia-Yu Chu, MD, PhD. Drug eruptions. UpToDate. Oct 03, 2016.
- Loricera J, Blanco R, Ortiz-Sanjuán F, et al. Single-organ cutaneous small-vessel vasculitis according to the 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides: a study of 60 patients from a series of 766 cutaneous vasculitis cases. Rheumatology (Oxford) 2015; 54:77.
- Simons FE, Ardusso LR, Dimov V, et al. World Allergy Organization Anaphylaxis Guidelines: 2013 update of the evidence base. Int Arch Allergy Immunol 2013; 162:193.
- Jennette JC, Falk RJ, Bacon PA, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum 2013; 65:1.
- Shinkai K, Stern R, Wintroub B. Reacciones farmacológicas cutáneas. Harrison. Principios de Medicina Interna. Volumen 1. 19º Edición. 377:390.
