Medium urgency
-Moderately severe
It is a disease that involves anemia, platelet deficiency and renal failure. It usually affects children between 1 month and 3 years of age.
The most frequent cause is a gastrointestinal infection by intestinal bacteria (enterobacteria, such as E. coli).
It manifests with gastrointestinal symptoms of abdominal pain, fever, vomiting and diarrhea with mucus and blood. After three days, the destruction of red blood cells causes asthenia, pallor and brownish urine.
Diagnosis is based on clinical examination, physical examination and blood tests.
Treatment should be administered in a hospital with blood transfusion, dialysis and immunosuppressive treatment in the most severe cases.
- Lucio Luzzatto. Anemias hemolíticas y anemia consecutiva a hemorragia aguda. Harrison. Principios de Medicina Interna. Volumen 2. 19ª Edición. Pág: 657.
- Barbara A. Konkle. Trastornos de las plaquetas y la pared vascular. Harrison. Principios de Medicina Interna. Volumen 2. 19ª Edición. Pág: 730.
- Patrick Niaudet. Clinical manifestations and diagnosis of Shiga toxin-producing Escherichia coli (STEC) hemolytic uremic syndrome (HUS) in children. UpToDate, Jan 22, 2016.
- Noris M, Remuzzi G. Hemolytic uremic syndrome. J Am Soc Nephrol 2005; 16:1035.
- Loirat C. An international consensus approach to the management of atypical hemolytic uremic syndrome in children. Pediatr Nephrol 2016; 31:15.
- Tarr PI. Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome. Lancet 2005; 365:1073.
Dr. Patricia Sánchez
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