It is the decrease or absence in the blood of hormones produced by the thyroid gland. It is more frequent in women and in those over 60 years of age.
There are multiple causes among which are: autoimmune disorders (Hashimoto's disease), thyroid nodules, thyroiditis, surgical removal of the gland, a side effect of some medications, irradiation of the gland and hereditary or congenital hypothyroidism.
It manifests with fatigue, weight gain, facial swelling, intolerance to cold, joint and muscle pain, constipation, dry skin, fine and dry hair, decreased sweating, heavy or irregular menstrual periods, fertility problems, depression and decreased heart rate.
Diagnosis is clinical by interrogation, complete physical examination and blood tests, which show low thyroid hormone concentration.
Treatment is aimed at treating the triggering cause and correcting the hormone deficiency with a daily intake of synthetic thyroid hormone.
- Douglas S Ross. Diagnosis of and screening for hypothyroidism in nonpregnant adults. UpToDate. Dec 14, 2015.
- Douglas S Ross. Treatment of hypothyroidism. UpToDate. Feb 22, 2016.
- Aoki Y, Belin RM, Clickner R, et al. Serum TSH and total T4 in the United States population and their association with participant characteristics: National Health and Nutrition Examination Survey (NHANES 1999-2002). Thyroid 2007; 17:1211.
- Jonklaas J, Bianco AC, Bauer AJ, et al. Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid 2014; 24:1670.
- J. Larry Jameson, Susan J. Mandel, Anthony P. Weetman. Trastornos de la glándula tiroides. Harrison. Principios de Medicina Interna. Volumen 2. 19º Edición. 2289:2293.
- M. Foz. Enfermedades del tiroides. Farreras Rozman. Medicina Interna. Volumen 2. 12º edición.2016:2024.

