Liquid ecstasy poisoning - Gamma-hydroxybutyric

Medium urgency
-Moderately severe

Gamma-hydroxybutyric acid (GHB) is known as "liquid ecstasy" (although it is not an amphetamine). It is a recreational drug commonly used by teenagers and young adults, often in combination with alcohol, cocaine, and other synthetic drugs.

Its maximum effect occurs about 30 minutes after ingestion, and the duration depends on the amount consumed. Toxicity is dose-dependent, meaning that effects vary depending on the amount taken.

Desired effects include euphoria, disinhibition, a sense of well-being, and increased sexual stimulation. Similar to other sedatives, dose escalation can lead to typical symptoms associated with central nervous system (CNS) depression, potentially resulting in deep coma with respiratory depression, hypotension, and bradycardia.

Diagnosis is made by clinical interview and physical examination. Additional tests include blood and urine analysis, electrocardiogram, and chest x-ray.

Treatment includes individualized symptom control and support, with close monitoring in the hospital.

Bibliographic references
  1. Deborah L Zvosec, Stephen W Smith. Gamma hydroxybutyrate (GHB) intoxication. UpToDate. Aug 07, 2012.
  2. Johnston LD, O'Malley PM, Bachman JG, Schulenberg JE. Monitoring the Future National Results on Adolescent Drug Use: Overview of Key Findings 2010. Ann Arbor, MI: National Institute on Drug Abuse, National Institutes of Health, 2011:58.
  3. Drug Abuse Warning Network (DAWN). The DAWN Report: Trends in drug-related Emergency Department visits, 1994-2002 At a Glance. Rockville, MD: U.S. Department of Health and Human Services SAMHSA, Office of Applied Studies, 2003.
  4. Drug Abuse Warning Network (DAWN). Drug Abuse Warning Network, 2007: National Estimates of Drug-Related Emergency Department Visits. Rockville, MD: U.S. Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, Office of Applied Studies, 2010.
  5. Bronstein AC, Spyker DA, Cantilena LR Jr, et al. 2009 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 27th Annual Report. Clin Toxicol (Phila) 2010; 48:979.
  6. Beatriz Benito, Natividad Laín Terés. Intoxicación aguda por fármacos, drogas y setas. Manual de protocolos y actuación en urgencias. Hospital Virgen de la Salud, Complejo Hospitalario de Toledo. Tercera edición. 2010. 1020:1021.
  7. Indalecio Morán, Jaume Baldirà, Luís Marruecos, Santiago Nogué. Intoxicación por ketamina, gamma-hidroxi-butirato y fenciclidina. Intoxicación clínica. Capítulo 42. Páginas 513-519. Grupo Difusión. 
Author
Dr. Elvira Moreno
Copyright
© TeckelMedical 2026

Symptoms

    Coma


    Diminished state of consciousness


    Low blood pressure


    Dilated pupils


    Hypothermia

Pre-hospital care recommendations

Call medical assistance for instructions.