Mediterranean spotted fever

Low urgency
-Moderately severe

It is an acute, zoonotic infectious disease (animal disease transmitted to humans) caused by the bacterium Rickettsia conoriis.  

The transmitting agent is a tick.

After an incubation period, it begins suddenly with chills, high fever, joint and muscle pain, headache and abnormal intolerance to light. After 3-5 days, there are skin lesions which may appear at the site of the tick bite or on other areas of the skin, typically on the trunk and limbs.

It is diagnosed by a detailed clinical history, where a possible contact with ticks approximately 12 days before and a complete physical examination should be investigated. The diagnostic suspicion is confirmed by isolating the bacteria in cultures and by blood serology.

Treatment is antibiotic with Doxycycline and treatment of symptoms with antipyretics and analgesics.

Bibliographic references
  1. Daniel J Sexton, Micah T McClain. Other spotted fever group rickettsial infections. UpToDate. Apr 28, 2016.
  2. Parola P, Paddock CD, Socolovschi C, et al. Update on tick-borne rickettsioses around the world: a geographic approach. Clin Microbiol Rev 2013; 26:657.
  3. Rovery C, Brouqui P, Raoult D. Questions on Mediterranean spotted fever a century after its discovery. Emerg Infect Dis 2008; 14:1360.
  4. Sousa Rd, França A, Dória Nòbrega S, et al. Host- and microbe-related risk factors for and pathophysiology of fatal Rickettsia conorii infection in Portuguese patients. J Infect Dis 2008; 198:576.
  5. Pérez-de Pedro I, Macías-Vega N, Miranda-Candón I, Camps-García MT. [Severe Rickettsia conorii infection associated with hemophagocytic syndrome]. Enferm Infecc Microbiol Clin 2008; 26:597.
  6. Walker DHy cols. Rickettsiosis. Harrison. Manual de Medicina. 16º edición. 542-548.
Author
Dr. Elvira Moreno
Copyright
© TeckelMedical 2026

Symptoms

    Skin rash


    Black mark where you were bitten


    Multiple flat or slightly raised red blotches


    Rash on palms and soles


    High fever of 40ºC/104ºF or above

Symptoms to watch out for

Vomiting
Pain in the chest
High fever (102.2 ºF or more)
Severe belly pain

Self-care

Eat a balanced diet: increase consumption of fruits, vegetables, and white meats, and reduce consumption of fatty and fried foods.
Maintain a fluid intake of 6 - 8 cups per day.
Talk to your doctor about prescribing antibiotics.