Mediterranean spotted fever (Pediatrics - PEDS)

Medium urgency
-Moderately severe
Mediterranean spotted fever is an acute and zoonotic (disease transmitted from animals to humans) infectious disease caused by the bacterium Rickettsia conorii. The transmitting agent is a tick. After a period of incubation, it suddenly starts with shivering, high fever, joint and muscle pains, headache and abnormal sensitivity to light. After 3-5 days, skin lesions occur that can appear at the site of the tick bite or on other areas of the skin, typically on the trunk and limbs. It is diagnosed by taking a detailed medical history (possible exposure to ticks approximately 12 days before must be investigated), a full physical examination and it can be confirmed by isolating the bacteria in cultures and by performing serology blood tests. Treatment is antibiotics with doxycycline and treatment of the symptoms.
Bibliographic references
  1. Daniel J Sexton, Micah T McClain. Other spotted fever group rickettsial infections. UpToDate. Apr 28, 2016.
  2. Parola P, Paddock CD, Socolovschi C, et al. Update on tick-borne rickettsioses around the world: a geographic approach. Clin Microbiol Rev 2013; 26:657.
  3. Rovery C, Brouqui P, Raoult D. Questions on Mediterranean spotted fever a century after its discovery. Emerg Infect Dis 2008; 14:1360.
  4. Sousa Rd, França A, Dória Nòbrega S, et al. Host- and microbe-related risk factors for and pathophysiology of fatal Rickettsia conorii infection in Portuguese patients. J Infect Dis 2008; 198:576.
  5. Pérez-de Pedro I, Macías-Vega N, Miranda-Candón I, Camps-García MT. [Severe Rickettsia conorii infection associated with hemophagocytic syndrome]. Enferm Infecc Microbiol Clin 2008; 26:597.
  6. Walker DHy cols. Rickettsiosis. Harrison. Manual de Medicina. 16º edición. 542-548.
Author
Dr. Elvira Moreno
Copyright
© TeckelMedical 2026

Symptoms

    Fever / Feel very hot


    Black mark where you were bitten


    Rash on palms and soles


    Fever between 39ºC / 102.2ºF and 39.9ºC / 103.82ºF


    High fever of 40ºC/104ºF or above