Serotonin reuptake inhibitors poisoning, SSRI - Serotonin syndrome

Serotonin reuptake inhibitors are drugs that are typically used as antidepressants. They act by increasing levels of serotonin (neurotransmitter or substance that transmits nerve impulses) in the brain. This potentially life-threatening condition may arise from the use of these medications, inadvertent interactions and intentional overdose. Symptoms include tachycardia and hypertension, hyperthermia (fever), involuntary sudden movements, tremor, dry mouth and sweating. Diagnosis of serotonin syndrome is only made by classical clinical signs in the context of taking the drugs listed. No laboratory test confirms diagnosis. Treatment varies depending on the severity of the disease and includes stopping taking the medication, normalization of vital signs and sedation with benzodiazepines. In severe cases, drugs will be given to counteract the effects of serotonin.