Basal cell skin carcinoma - Basal cell carcinoma

Medium urgency
-Moderately severe

Basal cell carcinoma is a type of cancer that originates in the basal cells of the skin. These cells are responsible for generating new cells when old ones die.

It can appear at any age, but becomes more common with advancing age. It typically affects individuals with fair skin and freckles and is uncommon in those with darker skin tones.

Prolonged exposure to the sun's ultraviolet light is the most common cause. Other risk factors include skin radiation during radiotherapy or immunosuppressive treatment, and contact with arsenic. There is also a genetic component, with the condition appearing in people with a personal or family history of skin cancer.

It manifests as a small lump or ulcer on sun-exposed areas of skin, such as the face and neck. The lesion is usually transparent, allowing the small blood vessels inside to be seen. It may have more or less well-defined, shiny edges. It can develop into an ulcer that tends to bleed easily when rubbed. Less common forms include brown, black or bluish lesions or flat, reddish patches that may peel. The least common type may appear as a whitish, waxy-looking scar.

Diagnosis is clinical, based on questioning the patient and examining the lesion. The type of cancer will be confirmed by a skin biopsy.

Treatment involves surgically removing the lesion. Other treatments include curettage and electrodesiccation, radiotherapy, photodynamic therapy, and treatments with creams or ointments, as well as cryosurgery using liquid nitrogen.

It is very rare for the cancer to spread and cause distant metastases. In such cases, chemotherapy and/or targeted drug therapy may be necessary.

You should consult a doctor if you notice a skin lesion that grows slowly and/or ulcerates or changes colour.

Bibliographic references
  1. Muzic JG, Schmitt AR, Wright AC, et al. Incidence and Trends of Basal Cell Carcinoma and Cutaneous Squamous Cell Carcinoma: A Population-Based Study in Olmsted County, Minnesota, 2000 to 2010. Mayo Clin Proc 2017; 92:890.
  2. Verkouteren JAC, Ramdas KHR, Wakkee M, Nijsten T. Epidemiology of basal cell carcinoma: scholarly review. Br J Dermatol 2017; 177:359.
  3. Goldenberg G, Karagiannis T, Palmer JB, et al. Incidence and prevalence of basal cell carcinoma (BCC) and locally advanced BCC (LABCC) in a large commercially insured population in the United States: A retrospective cohort study. J Am Acad Dermatol 2016; 75:957.
  4. Christenson LJ, Borrowman TA, Vachon CM, et al. Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years. JAMA 2005; 294:681.
  5. Gandini S, Doré JF, Autier P, et al. Epidemiological evidence of carcinogenicity of sunbed use and of efficacy of preventive measures. J Eur Acad Dermatol Venereol 2019; 33 Suppl 2:57.
  6. Wehner MR, Shive ML, Chren MM, et al. Indoor tanning and non-melanoma skin cancer: systematic review and meta-analysis. BMJ 2012; 345:e5909.
Author
Dr. Oscar Garcia-Esquirol
Copyright
© TeckelMedical 2026

Symptoms

    Flat, white, waxy-looking skin lesion


    Skin lump is translucent


    Nodule on the face


    Skin ulcer


    Nose ulcer