Diabetic ketoacidosis

Medium urgency
Very commonModerately severe

It is a decompensation of metabolism in diabetic patients, usually those who are insulin-dependent (type I). It is a common form of diabetes onset in many people.

It is caused by insufficient insulin in the blood, which prevents the body from using glucose as a source of energy. Instead, the body uses fats, generating acids that accumulate in the blood called ketones, which are excreted in the urine.

It manifests with rapid breathing, dry skin and mucous membranes, intense thirst, fruity-smelling breath, nausea-vomiting, abdominal pain, fatigue, decreased appetite and, after a few hours, decreased consciousness.

Diagnosis is made by questioning, physical examination and blood tests.

Treatment should be started immediately in a hospital: administration of insulin, abundant serum therapy, correction of internal metabolism (potassium and acidosis); vital signs should be monitored regularly.

It is considered a medical emergency that can be life-threatening within a few hours. Warning signs: decreased level of consciousness and accelerated breathing (greater than 25 breaths/minute).

Bibliographic references
  1. Irl B Hirsch, Michael Emmett. Diabetic ketoacidosis and hyperosmolar hyperglycemic state in adults: Clinical features, evaluation, and diagnosis. UpToDate. Sep 15, 2016.
  2. Irl B Hirsch, Michael Emmett. Diabetic ketoacidosis and hyperosmolar hyperglycemic state in adults: Epidemiology and pathogenesis. UpToDate. Jul 05, 2016.
  3. Irl B Hirsch, Michael Emmett. Diabetic ketoacidosis and hyperosmolar hyperglycemic state in adults: Treatment. UpToDate. Dec 07, 2015.
  4. Llamazares Iglesias O, Peña Cortés V, López López J, Sentenac Merchán JG. Urgencias en el diabético. Hierglicemia. Cetoacidosis. Síndrome Hiperosmolar. Manual de protocolos y actuación en urgencias. Hospital Virgen de la Salud, Complejo Hospitalario de Toledo. Tercera edición. 2010: 951-959.
  5. Savage MW, Dhatariya KK, Kilvert A, et al. Joint British Diabetes Societies guideline for the management of diabetic ketoacidosis. Diabet Med 2011; 28:508.
  6. Nyenwe EA, Kitabchi AE. Evidence-based management of hyperglycemic emergencies in diabetes mellitus. Diabetes Res Clin Pract 2011; 94:340.
  7. Westerberg DP. Diabetic ketoacidosis: evaluation and treatment. Am Fam Physician. 2013;87:337-46.
Author
Dr. Sara Vitoria
Copyright
© TeckelMedical 2026

Symptoms

    Vomiting


    Signs of dehydration


    Thirst


    Generalised abdominal pain


    Diminished level of consciousness

Pre-hospital care recommendations

Maintain hydration of 2 litres per day.
Call medical assistance for instructions.