Disseminated Intravascular Coagulation - DIC

Medium urgency
-Very severe

Disseminated intravascular coagulation (DIC) is a disorder of the proteins that control blood clotting. Initially, these proteins are activated to form small clots that block blood vessels, and later they are depleted, leading to bleeding due to the inability to clot.

The most common triggers are infection, inflammation and neoplastic disease.

The most common symptoms are bleeding, bruising and low blood pressure.

Diagnosis requires a detailed medical history and a thorough physical examination. Blood tests that quantify clotting factors are used to make a reliable diagnosis.

There is no specific treatment, but depending on the stage of the disease, it may be necessary to transfuse plasma or give heparin. The most important thing is to treat the underlying cause.

Bibliographic references
  1. Lawrence LK Leung. Clinical features, diagnosis, and treatment of disseminated intravascular coagulation in adults. UpToDate. Aug 23, 2016.
  2. Hellum M, Øvstebø R, Brusletto BS, et al. Microparticle-associated tissue factor activity correlates with plasma levels of bacterial lipopolysaccharides in meningococcal septic shock. Thromb Res 2014; 133:507.
  3. Liaw PC, Ito T, Iba T, et al. DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC. Blood Rev 2016; 30:257.
  4. Martinod K, Wagner DD. Thrombosis: tangled up in NETs. Blood 2014; 123:2768.
  5. Martinod K, Demers M, Fuchs TA, et al. Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice. Proc Natl Acad Sci U S A 2013; 110:8674.
  6. Handin RI. Trastornos hemorrágicos y trombóticos. Harrison. Manual de Medicina. 16º edición. 286-290.
Author
Dr. Elvira Moreno
Copyright
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Symptoms

    Red spotting on the skin - petechiae


    Superficial bruising on the skin


    Blood in urine


    Cough up pink mucus


    Brused joints