Erythroderma

Medium urgency
-Moderately severe

Erythroderma is said to occur when 90% or more of the body's skin surface is red and peeling.

It occurs as a complication of another skin condition, as a reaction to medication or as a manifestation of cancer. In up to 25% of cases, the cause is never found.

It appears as hardened, bright red patches that are itchy and grow slowly until they join together to cover a large part of the body's surface. These reddened areas are accompanied by scaling, usually in areas of flexion of the arms and legs.

The diagnosis is made by a physical examination of the skin and interview to determine the cause.

Treatment should include proper nutrition, correction of any hydro-electrolyte imbalance, maintenance of the skin's barrier function, the use of antihistamines to treat itching and antibiotics if secondary bacterial infection is suspected.

Bibliographic references
  1. A. Egeberg, J. Thyssen, G. Gislason, L. Skov. Prognosis after hospitalization for erythroderma. Acta Derm Venereol., 96 (2014), pp. 0
  2. Hebra FR. On Diseases of the skin. Vol. 2. En: Tay W, editor. London: TNSS; 1868. 69 p. 
  3. V.N. Sehgal, G. Srivastava, K. Sardana. Erythroderma/exfoliative dermatitis: A synopsis. Int J Dermatol., 43 (2004), pp. 39-47
  4. Diagnostic approach of erythroderma in the adult. Maldonado-García CA, Orozco-Anahuati AP. Rev Med Inst Mex Seguro Soc. 2017 May-Jun;55(3):353-360. 
  5. Exfoliative erythroderma. Milavec-Puretić V, Zorić Z, Zidanić M, Drcelić A, Stajminger G. Acta Dermatovenerol Croat. 2007;15(2):103-7. 
  6. A Practical Approach to the Diagnosis and Treatment of Adult Erythroderma. Cuellar-Barboza A, Ocampo-Candiani J, Herz-Ruelas ME. Actas Dermosifiliogr. 2018 Nov;109(9):777-790. doi: 10.1016/j.ad.2018.05.011. Epub 2018 Oct 10. 
  7. Erythroderma. Rothe MJ, Bialy TL, Grant-Kels JM. Dermatol Clin. 2000 Jul;18(3):405-15. 
  8. A review of the diagnosis and management of erythroderma (generalized red skin). Mistry N, Gupta A, Alavi A, Sibbald RG. Adv Skin Wound Care. 2015 May;28(5):228-36; quiz 237-8. doi: 10.1097/01.ASW.0000463573.40637.73. 

 

 
Author
Dr. Oscar Garcia-Esquirol
Copyright
© TeckelMedical 2026

Symptoms

    Skin irritation with flaking patches


    Scales on the skin


    Generalised skin reddening


    Itchy skin


    Skin with scaly red patches

Pre-hospital care recommendations

Antihistamines in syrup or tablet form for itching.
Relative rest, rest until symptoms subside.