Herpes simplex virus genital infection - HSV

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Genital herpes is the most common sexually transmitted disease caused by the herpes simplex virus (HSV).

There are 2 types of herpes simplex (HSV): HSV type 1 (HSV-1), often affecting mouth and lips, and HSV type 2 (HSV-2) which usually produces genital herpes. It is transmitted by vaginal, anal or oral sexual contact by someone infected. After the initial infection, the virus remains unactive in the body and can reactivate after some time. An infected person can be contagious without having any visible lesions; mothers can inffect their babies during labour.

Symptoms appear in outbreaks. Genital herpes can cause pain, itching and blisters in the genital area. Blisters are welts that break and turn painful. They usually appear around the area where the virus entered the body. Sometimes, the people infected don't know they have herpes due to being asymptomatic or having very mild symptoms. In the initial outbreak, which tends to be more acute, systematic symptoms such as fever and general malaise may appear.

The diagnosis is established through a detailed clinical history, complete physical examination and a lesion culture. It can be determined through the antibodies count against the virus.

Although there is no cure, it should be treated with analgesics and applying cold packs directly onto the ulcers. The antiretroviral drug acyclovir can relieve the symptoms and its duration, decrease the duration of the outbreaks, reduce the frequency of their recurrence and minimise its transmission. Preservatives help prevent the propagation of a herpes genital infection.

Bibliographic references
  1. Mary A Albrecht. Epidemiology, clinical manifestations, and diagnosis of genital herpes simplex virus infection. UpToDate. Feb 29, 2016.
  2. Bernstein DI, Bellamy AR, Hook EW 3rd, et al. Epidemiology, clinical presentation, and antibody response to primary infection with herpes simplex virus type 1 and type 2 in young women. Clin Infect Dis 2013; 56:344.
  3. Bradley H, Markowitz LE, Gibson T, McQuillan GM. Seroprevalence of herpes simplex virus types 1 and 2--United States, 1999-2010. J Infect Dis 2014; 209:325.
  4. Workowski KA, Bolan GA, Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep 2015; 64:1.
  5. Centers for Disease Control and Prevention (CDC). Seroprevalence of herpes simplex virus type 2 among persons aged 14-49 years--United States, 2005-2008. MMWR Morb Mortal Wkly Rep 2010; 59:456.
  6. Corey L.Virus del herpes simple. Harrison. Manual de Medicina. 16º edición. 553-562.
  7. Herpes Simplex Virus: Epidemiology, Diagnosis, and Treatment. Cole S. Nurs Clin North Am. 2020 Sep;55(3):337-345. doi: 10.1016/j.cnur.2020.05.004. Epub 2020 Jul 15. 
  8. Genital ulcers caused by herpes simplex virus. Parra-Sánchez M. Enferm Infecc Microbiol Clin (Engl Ed). 2019 Apr;37(4):260-264. doi: 10.1016/j.eimc.2018.10.020. Epub 2018 Dec
    21. 
  9. Genital Herpes: Insights into Sexually Transmitted Infectious Disease. Jaishankar D,Shukla D. Microb Cell. 2016 Jun 27;3(9):438-450. doi: 10.15698/mic2016.09.528.
Author
Dr. Elvira Moreno
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© TeckelMedical 2026

Symptoms

    Genital vesicles that turn into painful ulcers


    Painful pubic vesicles


    Blisters in the anal and genital region


    Blisters larger than 0.5 cm


    Lymph nodes are painful to the touch

Symptoms to watch out for

Fever (temperature higher than 38 ºC)
Headache
If it is accompanied by seizures
Neck stiffness
Reddened and painful ulcer in the affected area
Reddish sores that are itchy, break open, and ooze clear fluid or pus

Self-care

Consume over-the-counter pain relievers or anti-inflammatories.
Apply cold compresses 3 times a day for 20 minutes to reduce the symptoms.
Use a condom during oral, anal and vaginal intercourse.
Check with your general practitioner about the prescription for antiviral treatment.