HIV virus infection

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HIV or Human Immunodeficiency Virus is a retrovirus that attacks the immune system. It destroys white blood cells, specifically, CD4 lymphocytes, which are the cells in charge of manufacturing antibodies to combat infections. The final stage of infection by the virus is called AIDS. It means “acquired immunodeficiency syndrome” and not everybody with HIV develops it.

Infection by HIV occurs solely through the following fluids of infected people: blood, semen, vaginal discharge, preseminal fluid and mother’s milk. It is not transmitted by mosquitoes, ticks or other insects. Neither is it transmitted via conversation, shaking hands, sneezing, sharing plates or drinks, bathrooms, telephones or computers. It is not transmitted in saliva, tears or sweat.

Once HIV enters the body, three phases occur. In the first, patients may feel as if they have the flu for weeks. A large amount of the virus exists in the blood so the infection can be transmitted easily. In the second phase, patients may be asymptomatic for several decades without developing AIDS. The virus remains active but reproduces at very low levels. In the third phase, the viral load is high and furthermore serious deterioration of the immune system occurs, leading to the appearance of opportunistic infections and/or neoplasms.

Analysis is undertaken to detect antibodies against the virus in blood or saliva. When the body is infected with HIV, it begins to produce antibodies to try to combat the virus. HIV detection tests search for the presence of these antibodies, not the virus itself.

Medication against HIV, or antiretroviral drugs, stop the virus from reproducing, reducing its viral load. Since there is a lower concentration of HIV in the organism, the immune system has a greater possibility of recovering though it cannot thoroughly eliminate the virus. The immune system is strong enough to combat the infections and certain types of cancer related to HIV. Treatment furthermore reduces the risk of HIV transmission.

No definitive cure exists, making HIV a chronic disease. With suitable medical care and treatment, it can be controlled. Treating the disease as soon as possible means that patients’ life expectancies are increasingly higher.

Bibliographic references
  1. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. Available at http://aidsinfo.nih.gov/contentfiles/lvguidelines/AdultandAdolescentGL.pdf (Accessed on August 05, 2019).
  2. Robb ML, Eller LA, Kibuuka H, et al. Prospective Study of Acute HIV-1 Infection in Adults in East Africa and Thailand. N Engl J Med 2016; 374:2120.
  3. Ridzon R, Gallagher K, Ciesielski C, et al. Simultaneous transmission of human immunodeficiency virus and hepatitis C virus from a needle-stick injury. N Engl J Med 1997; 336:919.
  4. Kared H, Lelièvre JD, Donkova-Petrini V, et al. HIV-specific regulatory T cells are associated with higher CD4 cell counts in primary infection. AIDS 2008; 22:2451.
  5. Niu MT, Stein DS, Schnittman SM. Primary human immunodeficiency virus type 1 infection: review of pathogenesis and early treatment intervention in humans and animal retrovirus infections. J Infect Dis 1993; 168:1490.
  6. Daar ES, Little S, Pitt J, et al. Diagnosis of primary HIV-1 infection. Los Angeles County Primary HIV Infection Recruitment Network. Ann Intern Med 2001; 134:25.
  7. Braun DL, Kouyos RD, Balmer B, et al. Frequency and Spectrum of Unexpected Clinical Manifestations of Primary HIV-1 Infection. Clin Infect Dis 2015; 61:1013.
  8. Crowell TA, Colby DJ, Pinyakorn S, et al. Acute Retroviral Syndrome Is Associated With High Viral Burden, CD4 Depletion, and Immune Activation in Systemic and Tissue Compartments. Clin Infect Dis 2018; 66:1540.
  9. Daar ES, Pilcher CD, Hecht FM. Clinical presentation and diagnosis of primary HIV-1 infection. Curr Opin HIV AIDS 2008; 3:10.
  10. Kelley CF, Barbour JD, Hecht FM. The relation between symptoms, viral load, and viral load set point in primary HIV infection. J Acquir Immune Defic Syndr 2007; 45:445.
  11. Lavreys L, Baeten JM, Chohan V, et al. Higher set point plasma viral load and more-severe acute HIV type 1 (HIV-1) illness predict mortality among high-risk HIV-1-infected African women. Clin Infect Dis 2006; 42:1333.
  12. McKellar MS, Cope AB, Gay CL, et al. Acute HIV-1 infection in the Southeastern United States: a cohort study. AIDS Res Hum Retroviruses 2013; 29:121.
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