Mediterranean spotted fever (Paediatrics)

Medium urgency
-Moderately severe

It is an acute, zoonotic (animal disease transmitted to humans) infectious disease caused by the bacterium Rickettsia conoriis.

The transmitting agent is a tick.

After an incubation period, it begins suddenly with chills, high fever, joint and muscle pain, headache and abnormal intolerance to light. After 3-5 days, skin lesions develop, which may appear at the site of the tick bite or on other areas of the skin, typically on the torso and limbs.

It is diagnosed by a detailed clinical history (a possible contact with ticks should be investigated approximately 12 days before), complete physical examination and can be confirmed by isolating the bacteria in cultures and by blood serology.

Treatment is antibiotic with doxycycline and treatment of symptoms.

Bibliographic references
  1. Daniel J Sexton, Micah T McClain. Other spotted fever group rickettsial infections. UpToDate. Apr 28, 2016.
  2. Parola P, Paddock CD, Socolovschi C, et al. Update on tick-borne rickettsioses around the world: a geographic approach. Clin Microbiol Rev 2013; 26:657.
  3. Rovery C, Brouqui P, Raoult D. Questions on Mediterranean spotted fever a century after its discovery. Emerg Infect Dis 2008; 14:1360.
  4. Sousa Rd, França A, Dória Nòbrega S, et al. Host- and microbe-related risk factors for and pathophysiology of fatal Rickettsia conorii infection in Portuguese patients. J Infect Dis 2008; 198:576.
  5. Pérez-de Pedro I, Macías-Vega N, Miranda-Candón I, Camps-García MT. [Severe Rickettsia conorii infection associated with hemophagocytic syndrome]. Enferm Infecc Microbiol Clin 2008; 26:597.
  6. Walker DHy cols. Rickettsiosis. Harrison. Manual de Medicina. 16º edición. 542-548.
Author
Dr. Elvira Moreno
Copyright
© TeckelMedical 2026

Symptoms

    Fever / Feel very hot


    Black mark at site of the bite


    Rash on palms and soles


    Fever between 39ºC and 39.9ºC


    High fever of 40ºC or above