Mediterranean spotted fever

Low urgency
-Moderately severe

Acute and zoonotic (disease transmitted from animals to humans) infectious disease caused by the bacterium Rickettsia conorii.

The transmitting agent is a tick.

After a period of incubation, it suddenly starts with shivering, high fever, joint and muscle pains, headache and abnormal sensitivity to light. After 3-5 days, it produces cutaneous lesions that can appear at the site of the tick bite or on other areas of the skin, typically on the torso and limbs.

It is diagnosed with a detailed medical history, in which a possible exposure to ticks approximately 12 days before must be investigated, and a full physical examination. The diagnosis is confirmed by isolating the bacteria in cultures and by performing serology blood tests.

The treatment approach is antibiotic with doxycycline and treatment of the symptoms with antipyretics and analgesics.

Bibliographic references
  1. Daniel J Sexton, Micah T McClain. Other spotted fever group rickettsial infections. UpToDate. Apr 28, 2016.
  2. Parola P, Paddock CD, Socolovschi C, et al. Update on tick-borne rickettsioses around the world: a geographic approach. Clin Microbiol Rev 2013; 26:657.
  3. Rovery C, Brouqui P, Raoult D. Questions on Mediterranean spotted fever a century after its discovery. Emerg Infect Dis 2008; 14:1360.
  4. Sousa Rd, França A, Dória Nòbrega S, et al. Host- and microbe-related risk factors for and pathophysiology of fatal Rickettsia conorii infection in Portuguese patients. J Infect Dis 2008; 198:576.
  5. Pérez-de Pedro I, Macías-Vega N, Miranda-Candón I, Camps-García MT. [Severe Rickettsia conorii infection associated with hemophagocytic syndrome]. Enferm Infecc Microbiol Clin 2008; 26:597.
  6. Walker DHy cols. Rickettsiosis. Harrison. Manual de Medicina. 16º edición. 542-548.
Author
Dr. Elvira Moreno
Copyright
© TeckelMedical 2026

Symptoms

    Skin rash


    Black mark at site of the bite


    Multiple flat or slightly raised red bumps


    Rash on palms and soles


    High fever of 40ºC or above

Symptoms to watch out for

Vomiting
Pain in the chest
High fever (39 ºC or more)
Acute belly pain

Self-care

Maintain a balanced diet: increase fruit, vegetable, and white meat consumption and reduce the intake of fatty meals and fritters.
Maintain hydration of 2 litres per day.
Check with your general practitioner about the prescription for antibiotics.