Mouth tumour - Squamous cell carcinoma

Medium urgency
-Moderately severe

Mouth cancer is considered to be any cancer that appears between the lips in front, and on the back of the tongue and palates. The most common type is squamous cell carcinoma. 

It is directly related to alcohol consumption and smoking, especially when two packs a day are smoked.

It manifests as a reddish or whitish lesion on the mucosa of the floor of the mouth, on the edges or at the base of the tongue, as well as on the inside of the cheeks. It usually has a surrounding rim and feels harder than the rest of the mucosa. It may look like an ulcer or a lump growing towards the inside of the mouth. In more advanced stages it may be accompanied by pain in the mouth and difficulty in swallowing food.

In up to 30% of cases the lesion may appear on the lower lip, in which case it is related to prolonged exposure to the sun.  

Diagnosis is usually made by direct observation of the lesion at the dentist's office. To confirm the diagnosis, a biopsy or brushing of the lesion will be performed. Sometimes laryngoscopy and/or oesophagoscopy will be performed in addition to other imaging tests, such as chest X-rays or CT-scans, to complete the extension study.

Treatment is surgical, completed with chemotherapy or postoperative radiotherapy depending on the case.

Survival varies depending on whether the cancer remains confined to the mouth or has spread. Survival of localised tongue or floor of the mouth cancer is over 75% at 5 years, but if there is metastasis of the tumours, survival drops to half.

Bibliographic references
  1. Carcinoma of the Buccal Mucosa. Dinesh K. Chhetri MD, Jeffrey D. Rawnsley MD, Thomas C. Calcaterra MD. First published: 01 September 2016. https://doi.org/10.1067/mhn.2000.110539.
  2. Squamous cell carcinoma of tongue and buccal mucosa: clinico-pathologically different entities. Sudhir Nair 1, Bikramjit Singh 2 3, Prashant V Pawar 1 4, Sourav Datta 1, Deepa Nair 1, Shubhada Kane 5, Pankaj Chaturvedi 1. Eur Arch Otorhinolaryngol. 2016 Nov;273(11):3921-3928. doi: 10.1007/s00405-016-4051-0. Epub 2016 Apr 20.
  3. Squamous cell carcinoma of buccal mucosa: a 40-year review. DeConde A, Miller ME, Palla B, Lai C, Elashoff D, Chhetri D, St John MA. Am J Otolaryngol. 2012 Nov-Dec;33(6):673-7. doi: 10.1016/j.amjoto.2012.04.006. Epub 2012 Jun 6. PMID: 22681929.
  4. Carcinoma of the buccal mucosa: analysis of clinical presentation, outcome and prognostic factors. Ghoshal S, Mallick I, Panda N, Sharma SC. Oral Oncol. 2006 May;42(5):533-9. doi: 10.1016/j.oraloncology.2005.10.005. Epub 2006 Feb 7. PMID: 16464632.
  5. Clinicopathological characteristics of oral squamous cell carcinoma arising from oral submucous fibrosis: A systematic review. Divya B, Vasanthi V, Ramadoss R, Kumar AR, Rajkumar K.
  6. J Cancer Res Ther. 2023 Apr-Jun;19(3):537-542. doi: 10.4103/jcrt.jcrt_1467_21. PMID: 37470571.
Author
Dr. Oscar Garcia-Esquirol
Copyright
© TeckelMedical 2026

Symptoms

    Hard, red lesion on floor of mouth and/or base of tongue


    Whitish tongue patch


    Whitish patch on the inner side of the cheek


    Lump inside the mouth


    Bottom of the mouth is swollen