Peripheral arterial disease

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It is the progressive, chronic obstruction of the arteries carrying blood flow to the legs and feet.

It is caused by accumulated plaque (atherosclerosis) on the artery walls. Atherosclerosis risk factors are: having more than 65 years old, diabetes, smoking, arterial hypertension and/or hypercholesterolaemia.

Most people present no to mild symptoms. The main symptom is pain or muscle cramps in the legs, especially at calf level. It appears when walking and disappears at rest. Other symptoms: numbness; weakness; feeling of coldness in the leg or foot; wounds that do not heal from lack of bloodflow; change in colour of the leg's skin; hair loss; slow growth of nails; weak pulse in the the extremity, and, erectile dysfunction.

Diagnosis is done using the ankle-brachial index, which is suggestive when the ABI is lower than 0.8. A lower-limb Doppler ultrasound, arteriograph, or CT angiogram are other frequent tests.

The treatment has the aim of improving leg blood flow and avoiding the appearance of ulcers and gangrene. Doing exercise is recommended; take care of one's feet to avoid injuries while keeping them clean and well moisturised with the nails properly cut; wear comfortable shoeware with no seams; avoid compression stockings or pantyhose. Control cardiovascular risk factors. In severe cases, an angioplasty and/or surgery to recover blood flow in the limb may be necessary.

Since atherosclerosis is a generalised disease that affects several regions of the body, these patients have a higher risk of suffering a heart attack (acute myocardial infarction) or stroke.

Bibliographic references
  1. Bonaca MP, Creager MA. Peripheral artery diseases. In: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 11th ed. Philadelphia, PA: Elsevier; 2019:chap 64.
  2. Kullo IJ. Peripheral artery disease. In: Kellerman RD, Rakel DP, eds. Conn's Current Therapy 2019. Philadelphia, PA: Elsevier; 2019:141-145.
  3. Simons JP, Robinson WP, Schanzer A. Lower extremity arterial disease: medical management and decision making. In: Sidawy AN, Perler BA, eds. Rutherford's Vascular Surgery and Endovascular Therapy. 9th ed. Philadelphia, PA: Elsevier; 2019:chap 105.
  4. Ridker PM, Libby P, Buring JE. Risk markers and the primary prevention of cardiovascular disease. In: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 11th ed. Philadelphia, PA: Elsevier; 2019:chap 45.
  5. Simons JP, Robinson WP, Schanzer A. Lower extremity arterial disease: medical management and decision making. In: Sidawy AN, Perler BA, eds. Rutherford's Vascular Surgery and Endovascular Therapy. 9th ed. Philadelphia, PA: Elsevier; 2019:chap 105.
  6. US Preventive Services Task Force, Curry SJ, Krist AH, Owens DK, et al. Screening for peripheral artery disease and cardiovascular disease risk assessment with the ankle-brachial index: US Preventive Services Task Force Recommendation Statement. JAMA. 2018;320(2):177-183. 
  7. White CJ. Atherosclerotic peripheral arterial disease. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 71.
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Symptoms

    Pain in the calves when walking


    Cramps in the calves


    Sores due to poor blood flow in toes and/or the heel


    Colour change of the foot


    Both legs are numb

Symptoms to watch out for

Headache
Pain in the chest
Excessive sudoration
Numbness or weakness on one side of the face
Loss of sensitivity and/or motility in limbs

Self-care

Maintain a balanced diet: increase fruit, vegetable, and white meat consumption and reduce the intake of fatty meals and fritters.
Maintain hydration of 2L per day. Avoid soft drinks and fruit juices with high sugar content.
Engage in regular physical activity, adapted to age and physical condition, at least 3 times a week.
Lose weight if you are overweight or obese.
Reduce tobacco consumption.
Clip and polish the nails.