Sudden exanthema - Roseola infantum or 6th disease (Paediatrics)

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Common-

Sudden exanthema (also known as infantile roseola or 6th disease) is a viral disease that mainly affects children between the ages of 3 months and 2 years.

The herpes 6 or 7 virus is transmitted between infected and healthy people through the respiratory tract in small droplets of saliva and/or mucus.

The most common symptoms are a moderate to high fever for 3-4 days, which disappears before giving way to a rash of reddish, usually non-itching spots, especially on the torso, back and neck.

Diagnosis is made on the basis of a typical clinical history and physical examination, and no additional tests are required.

As it is a viral infection, there is no specific treatment, only management of the symptoms (antipyretic treatment for fever and plenty of fluids). The course of the disease is generally very good, with symptoms disappearing 24-72 hours after the fever has gone.

Bibliographic references
  1. Stone RC, Micali GA, Schwartz RA. Roseola infantum and its causal human herpesviruses. Int J Dermatol. 2014 Apr;53(4):397-403. Review.
  2. Tesini BL, Epstein LG, Caserta MT. Clinical impact of primary infection with roseoloviruses. Curr Opin Virol. 2014 Dec;9:91-6. doi: 10.1016/j.coviro.2014.09.013. Epub 2014 Oct 14. Review.
  3. Cherry JD. Roseola infantum (exanthem subitum). In: Feigin and Cherry’s Textbook of Pediatric Infectious Diseases, 7th ed, Cherry JD, Harrison GJ, Kaplan SL, et al (Eds), Elsevier Saunders, Philadelphia 2014. p.768
  4. Agut H, Bonnafous P, Gautheret-Dejean A. Laboratory and clinical aspects of human herpesvirus 6 infections. Clin Microbiol Rev 2015; 28:313.
  5. Laina I, Syriopoulou VP, Daikos GL, et al. Febrile seizures and primary human herpesvirus 6 infection. Pediatr Neurol 2010; 42:28.
Author
Dr. Maria Trabazo
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Symptoms

    Skin rash


    Fever the days before the rash appeared


    Fever between 39ºC and 39.9ºC


    Fever / Feel very hot


    Irritability

Symptoms to watch out for

Fever that doesn't subside with antipyretics (paracetamol, ibuprofen)
Symptom persistence for more than two weeks after the initial treatment

Self-care

Consume over-the-counter pain relievers or anti-inflammatories.
Relative rest, rest until symptoms subside.
Maintain hydration of 2 litres per day.
Antihistamines in syrup or tablet form for itching.