Transverse myelitis is inflammation of a segment of the spinal cord. It occurs most frequently between the ages of 10-19 years and 30-39 years.
In 15-30% of cases no trigger is found. It is sometimes attributed to a viral infection, an autoimmune reaction, insufficient blood flow or a demyelinating disease such as multiple sclerosis.
It manifests with symptoms below the area of swollen spinal cord. It usually presents as low back pain of rapid onset, with impaired sensation and mobility in the legs. It may be accompanied by alterations in bowel and urinary bladder function.
It is diagnosed by clinical history and physical examination with an exhaustive neurological study. The most informative imaging test is an MRI.
Treatment aims to reduce inflammation with corticosteroids as anti-inflammatories and the usual analgesics for pain control. It should be combined with rehabilitation.
About 30% of patients recover without sequelae, while others are left with permanent impairment.
- Chitra Krishnan, Benjamin Greenberg. Transverse myelitis. UpToDate. Mar 07, 2016.
- Mécharles S, Herrmann C, Poullain P, et al. Acute myelitis due to Zika virus infection. Lancet 2016; 387:1481.
- Kaplin AI, Krishnan C, Deshpande DM, et al. Diagnosis and management of acute myelopathies. Neurologist 2005; 11:2.
- Poulter MO, Payne KB, Steiner JP. Neuroimmunophilins: a novel drug therapy for the reversal of neurodegenerative disease? Neuroscience 2004; 128:1.
- Krishnan C, Kaplin AI, Pardo CA, et al. Demyelinating disorders: update on transverse myelitis. Curr Neurol Neurosci Rep 2006; 6:236.
- Hauser SL, Ropper AH. Enfermedades de la médula espinal. Harrison. Manual de Medicina. 16º edición. 991-992.
- Beh SC, Greenberg BM, Frohman T, Frohman EM. Transverse Myelitis.Neurol Clin. 2013 Feb;31(1):79-138. doi: 10.1016/j.ncl.2012.09.008.
- West TW, Hess C, Cree BA. Acute transverse myelitis: demyelinating, inflammatory, and infectious myelopathies. Semin Neurol. 2012 Apr;32(2):97-113. doi: 10.1055/s-0032-1322586
- Borchers AT1, Gershwin ME. Transverse myelitis. Autoimmun Rev. 2012 Jan;11(3):231-48. doi: 10.1016/j.autrev.2011.05.018.
- Waldrup BC. Identifying transverse myelitis in the emergency care arena. Adv Emerg Nurs J. 2009 Apr-Jun;31(2):131-9. doi: 10.1097/TME.0b013e3181a2957e
- Sá MJ. Acute transverse myelitis: a practical reappraisal. Autoimmun Rev. 2009 Dec;9(2):128-31. doi: 10.1016/j.autrev.2009.04.005

